Endocrine Abstracts

Background: Prevalence of hypogonadism is high (30%) in men with HIV. In these patients T treatment (TT) is currently used mainly to counteract wasting syndrome and/or HIV-related lipodystrophy, irrespective of patients’ serum T. However, its effect and safety in HIV-infected men is still not completely known.Aim: To investigate both beneficial and adverse effects related to TT in HIV-infected men using a meta-analytic approach.<p class="abstext...

Introduction: HIV infection treated with highly active antiretroviral therapy (HAART) seems to be associated with hypogonadism in men. Less is known in HIV-infected women gonadal status. The aim of this study is to investigate gonadal function, in menopausal HIV-infected women compared sex- and age-matched healthy subjects (HS).Methods: We retrospectively compared 188 HIV-infected women with 192 HS selected reviewing record charts and laboratory database...

Objective: Highly Active Antiretroviral therapy (HAART) has been associated with several endocrine abnormalities. Data concerning thyroid dysfunction in HIV are still controversial. The aim of this study was to investigate the prevalence of thyroid dysfunctions and their association with HAART and HIV-infection in a large cohort of HIV-infected patients.Methods: A retrospective cross-sectional study was carried out involving HIV-infected patients whose t...

Background: HIV-infection is associated to an increased prevalence of erectile dysfunction (ED). In HIV-infected men ED seems to be less related to serum Testosterone (T), depending from other factors.Aim: To investigate the role of different components (organic, relational, psychological) of erectile function by using validate questionnaires in HIV-infected men with normal serum T.Methodology: Prospective, cross-sectional, observa...

Introduction: Growth Hormone deficiency (GHD) is frequent in patients with human immunodeficiency virus 1 (HIV-1), undergoing highly active antiretroviral therapy. GHD seems to depend on HIV-related lipodystrophy and to be less frequent in women.Aim of the study: To investigate the association of gender, body composition and GH/IGF1 axis, and to clarify whether GHD in HIV-infected patients is functional or a clinical entity.Methods...

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)GH response to GHRH+Arg is impaired in HIV-infected men and women, compared to gender matched controls. Moreover, reduced GH secretion seems to occur more frequently in HIV-infected males than females.Methods: To determine gender effects on GH secretion in HIV-infected patients with lipodystrophy, we compared GH/IGF1 status and body composition in 103 males and 97 females. ...

Introduction: Among various comorbidities of human immunodeficiency virus-1 (HIV-1) infection, male hypogonadism is very frequent with a prevalence of 19% in patients treated with highly active anti-retroviral therapy. However, literature data are still lacking and achieved by studies with <300 subjects each.Aim of the study: Prevalence and clinical characterization of hypogonadism among a large number of men with HIV-1.Methods...

Introduction: HIV-infected patients often display a moderate to severe GH deficiency (GHD). To investigate the effects of r-hGH on hormonal parameters and body composition in patients with HIV-related lipodystrophy (HIV-r-L) and concomitant GHD, we studied 60 patients with HIV-r-L, 28 male and 32 females aged 18–65 years. According to their response to GHRH+Arginine (GH peak assumed to be normal when >7.5 ng/ml) patients were assigned to the following 3 groups: Group ...

Background: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (>3.5 if Ca and P are expressed in mg/dl) from healthy subjects [1]. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP), might impair the Ca/P ratio.Aim: To ...

Background: HIV is associated with decreased bone mineral density (BMD) and decreased muscle mass. Osteoporosis and sarcopenia often co-exist and their onset is multifactorial. Sex steroids play a key role in the homeostasis of bone health and body composition in HIV-uninfected men, but data in MLWH are scanty.Aim: To investigate the frequency of low BMD and sarcopenia and their relationship with gonadal function in MLWH younger than 50.<p class="abs...